Publisher: Elsevier BV

Issue: 7

License: https://www.elsevier.com/tdm/userlicense/1.0/

Publication date(s): 2018/04 (print)

Pages: 1314-1319

Volume: 26 Issue: 7

Journal: Bioorganic & Medicinal Chemistry

Link: https://api.elsevier.com/content/article/PII:S0968089617301268?httpAccept=text/xml

URL: http://dx.doi.org/10.1016/j.bmc.2017.03.068

Artemisinin is one of the most potent anti-malaria drugs and many often-lengthy routes have been developed for its synthesis. Amorphadiene synthase, a key enzyme in the biosynthetic pathway of artemisinin, is able to convert an oxygenated farnesyl diphosphate analogue directly to dihydroartemisinic aldehyde, which can be converted to artemisinin in only four chemical steps, resulting in an efficient synthetic route to the anti-malaria drug.

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