Publisher: Wiley

Issue: 38

License: http://doi.wiley.com/10.1002/tdm_license_1.1

Publication date(s): 2018/10/17 (print) 2018/08/20 (online)

Pages: 5282-5284

Volume: 2018 Issue: 38

Journal: European Journal of Organic Chemistry

Link: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejoc.201800799

URL: http://dx.doi.org/10.1002/ejoc.201800799

The “smart” amine donors o-xylylenediamine and cadaverine were employed for the rapid screening of a large ketone library and subsequent preparative-scale synthesis of selected compounds using a commercially available amine transaminase, ATA256. The methodology enables both screening and preparative-scale biotransformations to be performed with a single enzyme and simplifies the generation of sp3-rich small-molecule libraries.